Making use of single-molecule optical and AFM imaging and drive-spectroscopy tactics, we seek out to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our exploration passions include:
1996, 1st mesoscopic demand density waves products; and first electrical measurements on an individual metallic nanocluster among nanoelectrodes
Multicolor imaging of the bacterial nucleoid and cell division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. Inside only some months, we had been able to evaluate transport as a result of someone single-walled carbon nanotube. Determined by reduced-temperature experiments by a superb PhD pupil in my group, Sander Tans (now a valued colleague and professor at Delft University of Technologies having an active investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with incredibly extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
All parameters ended up the same for each panel On this movie, apart from the First placement of your 6hb rod (shown in blue) around the nanopore. Simulations that terminated early as a result of translocation on the rod from the pore are marked by a gray history.
2011, very first in vitro measurements of transport across a single biomimetic nuclear pore complex; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
What if, in lieu of employing standard major-down silicon electronics, transistors could possibly be built from The underside up utilizing solitary organic molecules as being the switching components? This concept, which became The idea of these days’s subject of molecular electronics, initial emerged from the 1970s.
It was in the course of this period that Dekker carried out investigate on magnetic spin methods and on noise in superconductors and semiconductors.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
2006, to start with demonstration https://www.ceesdekker.net of molecular sorting within a lab over a chip applying biomotors; discovery of nanobubbles in strong-condition nanopores; and initially estimate of electrokinetic energy conversion within a nanofluidic channel
2005, discovery on the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extended-vary conformational alterations in Mre11/DNA repair complexes; and 1st drive measurements on the DNA molecule in a very nanopore
Solid-point out nanopores have tested to be a surprisingly versatile probe for one-molecule Evaluation of DNA. I will describe some of our recent conclusions – precisely DNA knots – and our endeavours to develop the abilities of reliable-condition nanopores even additional, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.